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One pattern worth noting: patients switching from Rybelsus to Zepbound (or vice versa) often experience a second wave of GI side effects during re-titration, even if they tolerated the first drug well

The authors reported that in obese mice, daily AOD-9604 administration over 14 days produced significant reductions in body weight gain, decreases in adipose tissue mass, and increases in fat oxidation, with effect sizes comparable to those of full-length human growth hormone [1]