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In a randomized, controlled clinical study (Study F), in adult patients with type 2 diabetes not using oral antidiabetic medications (n = 518), a basal-bolus regimen of insulin glargine once daily at bedtime or NPH insulin administered once or twice daily was evaluated for 28 weeks
It acts on specific receptors in the brain that regulate appetite and food intake, leading to a decreased desire to eat
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But the effect is unproven, varies widely, and the medication was not designed to treat drinking
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