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These observations were further confirmed by Hoechst 33342 staining, which revealed extensive detachment of cells from the cell culture substratum and increases in apoptotic bodies of HepG2 cells incubated with H 2 O 2 and TNF for 16 h (Fig

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Therapeutic approaches to address copper ion metabolism abnormalities and the associated cardiovascular diseases Despite high levels of research into the understanding of the role of copper physiologically and pathophysiologically, there remain uncertainties regarding the accurate measurement of copper levels and the long-term effects of copper exposure on cardiovascular health (118)

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