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GIP/GLP-1 dual agonists such as tirzepatide additionally engage the GIP receptor, layering in a second incretin mechanism
The common research schedule is 812 weeks on, then about 4 weeks off , letting the GH/IGF-1 axis and receptor sensitivity reset before another cycle
Maintain your current dietary approach during the switch
Patients begin with a clinically appropriate starting dose and increase gradually based on individual tolerance and metabolic response, a strategy proven safer than fixed-dose protocols
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