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Part of this migratory effect can be attributed to the stimulation of IL-1 secretion by resident macrophages via MSU crystals, which subsequently instigates caspase-11 expression in macrophages through IL-1R and MYD88 (55)

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One of the most commonly reported side effects across GLP-1 types is nausea, a sick-to-the-stomach feeling that often creates an urge to vomit, and a loss of appetite

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