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Lixisenatide and exenatide used in ELIXA and EXSCEL trials are short-acting GLP-1RAs that are structurally similar to exendin-4, a peptide found in the saliva of the Gila monster Heloderma suspectum
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What matters is whether the glutathione reaches your bloodstream intact, and that depends almost entirely on the delivery system
It possesses in vitro balanced GIPR (EC50 = 3 pM) and GLP-1R (EC50 = 5 pM) agonism with relative activity seven times that of GIP to GIPR and five times that of GLP-1 to GLP-1R, respectively (44)
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