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This is relevant because muscle-related concerns with tirzepatide are common, and understanding how BMI category affects body composition changes helps set appropriate expectations

Robust statistical methods in R using the WRS2 package

The role of mGlu receptor signalling in pain modulation was recently reviewed in detail [36]

For some patients, a step-down option to a lower-burden oral GLP-1 is useful, either short-term to bridge the transition, or as a lighter form of long-term support if and when it is clinically appropriate