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GH release in the pituitary is primarily determined by the balance of these two peptides, which in turn is affected by many physiological stimulators (e.g., exercise, nutrition, sleep) and inhibitors (e.g., free fatty acids) of GH secretion

Cancers (Basel) 11 , 235, (2019)

However, many endogenous and exogenous factors such as free radicals produced by chronic inflammation in the body, certain metabolites of cells and gut microbiota [14], as well as chemical carcinogens in the environment [15], ultraviolet (UV) radiation attack intracellular DNA and may cause a variety of DNA damage [3]

7.2 Immune balance and tolerance: regulatory roles of probiotics 7.2.1 Cytokine reprogramming: anti-inflammatory and tolerogenic pathways Acting as essential molecular messengers, cytokines play a central role in orchestrating immune and inflammatory responses and regulate a wide spectrum of additional physiological processes (243)