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While collagen is relatively heat-stable, extreme temperatures can eventually break down the delicate peptide bonds, potentially reducing its effectiveness
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On the other hand, the activation of the neutrophiles takes part directly in the peroxidation of lipids of the membrane and causes directly the destruction of the cell 46
Targeted drug delivery by in vivo coupling to endogenous albumin: an albumin-binding prodrug of methotrexate (MTX) is better than MTX in the treatment of murine collagen-induced arthritis
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