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For those using Semaglutide GLP-1 for diabetes management , improvements in glucose control may appear within days, while weight management benefits generally become more noticeable over several weeks
The abdomen also tends to have less nerve density than the thigh at the specific insertion points used, which translates to less sensation during injection
Adherence data supports this preference, with injectable GLP-1s showing superior long-term compliance compared to oral obesity medications
When the effort required by rodents to obtain palatable food was assessed, exendin-4 was found to decrease operant responding on both fixed and progressive ratio schedules, further supporting a reduction in the motivational drive for palatable foods (Bernosky-Smith et al., 2016)
