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Semaglutide injections work because it imitates a hormone called Glucagon-Like Peptide-1 (GLP-1), which affects the part of the brain that controls hunger

Standard GLP-1 dosing schedules follow fixed timelines that may not feel suitable for everyone

Healthcare providers should assess: Body composition changes (not just weight) to evaluate muscle mass preservation Glycemic control in patients with diabetes, adjusting other medications as needed Thyroid function if symptoms of hypothyroidism develop (fatigue, cold intolerance) Nutritional status through clinical assessment and laboratory testing when indicated Patients experiencing excessive fatigue, cold intolerance, or other symptoms potentially indicating metabolic suppression should be evaluated promptly, though these symptoms more commonly relate to rapid weight loss itself rather than direct drug effects

From there, doses increased in 2-week intervals until reaching the target maintenance dose