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At the same time, trial designs are evolving to account for lean-mass considerations, maintenance dosing strategies, amylin analogs, and the growing documentation burden tied to prior GLP-1 exposure

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Corneal stromal stem cells (CSSCs)-derived and corneal MSCs-derived EVs modulate inflammatory responses during corneal wound healing through decreasing early neutrophil infiltration, changing macrophage phenotypes, and diminishing the production of inflammatory cytokines (91, 95, 98, 99) ( Figure 1 , Table 1 )