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We thus conclude, that ROXY9 and maybe other class III GRXs will not efficiently take part in reactions on glutathione mixed disulfides unless the GSH scaffold site is altered by an induced fit of a specific substrate

While rare, this is a medical emergency

On the other hand, we found that treating steatotic cells with 200 nM Ex-4 for 3 h is optimal for reducing lipid accumulation significantly (data not shown)