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Even with the improved convenience of once-daily options, the true breakthrough in adherence came with current-generation, once-weekly GLP-1 drugs

Comparing Semaglutide and Tirzepatide Uses Semaglutide has different indications, depending on the brand name medication: Wegovy: Weight loss, cardioprotection in patients with excess weight Ozempic: Glycemic control in patients with type 2 diabetes, cardioprotection/kidney protection in patients with type 2 diabetes and cardiovascular/kidney disease Rybelsus: Glycemic control in type 2 diabetes Tirzepatide is approved for the following, depending on the brand name medication: Zepbound: Weight loss, sleep apnea in adults with obesity Mounjaro: Glycemic control in patients with type 2 diabetes However, Ozempic and Mounjaro can also be prescribed for weight management off-label

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Henry JP, Bordoni B (2022) Histology, osteoblasts