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Having reviewed the literature and talked to 5+ individuals who have taken semaglutide, two downsides emerge: The weight will very likely come back on if you discontinue usage It is very difficult to maintain muscle mass while on these drugs Two images summarize these issues

Support for what your body already does GLP-1 is important for metabolic health and weight management, but medication isnt the only way to get levels where you want them

Copper in solution tends to oxidize, and this oxidation can damage the peptide structure over time

These effects are often mild and most people find they lessen over time as the body adjusts to the medication