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1,2 Following a meal, GLP-1 facilitates glucose-dependent insulin secretion from pancreatic -cells, suppresses glucagon release from -cells, and slows gastric emptying, all of which moderate glucose excursions following nutrient intake

Here's what we at Klinic recommend considering: Semaglutide might be better if: You have better insurance coverage for it You want a medication with a longer track record You prefer to start with something that might have a slightly gentler introduction period You'd rather take a pill than inject the Wegovy pill makes that possible You've responded well to GLP-1 medications in the past Tirzepatide might be better if: You're looking for maximum weight loss potential You want a medication developed specifically for weight loss You're willing to potentially deal with slightly more nausea initially You want a dual-action approach Your insurance covers it or you have budget flexibility Questions to ask yourself: What's your weight loss goal

Lee: These limitations are significant