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Together, these updates reflect the agencys evolving approach to drug regulation, access, and evidentiary standards
However, the SURMOUNT-5 trial compared tirzepatide to semaglutide 2.4mg (a more potent GLP-1 agonist than liraglutide), and tirzepatide still showed superior weight loss: 20.2% vs 13.7% at 72 weeks
Side effects affect the stomach or intestines but differ depending on the specific drug and dosage
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