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But certain symptoms warrant prompt medical review: Severe or persistent vomiting that prevents you from keeping fluids down Intense abdominal pain (particularly if it radiates to the back this could indicate pancreatitis) Signs of an allergic reaction: swelling of the face, lips or tongue, difficulty breathing, severe rash A lump or swelling in the neck, hoarseness or difficulty swallowing (potential thyroid concern) Yellowing of the skin or eyes (jaundice a sign of significant liver involvement) Symptoms of low blood sugar if you're also taking insulin or sulphonylureas: shakiness, sweating, confusion This isn't a reason to be alarmed these serious events were rare in trials

While triglyceride levels were assessed, additional metabolic or hepatic markers, including pre-treatment FT4 and urinary carnitine/acylcarnitine levels, were not available