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Potential risk of hypoglycemia in patients with heart failure
Whether this translates into meaningfully superior outcomes compared with approved agents can only be established through direct head-to-head trials, which have not yet been conducted
On the other hand, endogenous active ghrelin has a short plasma half-life of 1530 min (101) and is limited in its ability to cross the blood-brain barrier (102)
These medications work through entirely different mechanisms in the body and do not interfere with each other's pharmacological pathways
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