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Monotherapy versus Combination Therapy The decision to initiate drug therapy with metformin alone or in combination with another agent is influenced by HbA1C level and health status when diabetes is newly diagnosed

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The results demonstrated a very strong accumulation of ROS inside the hypoxic cancer cells upon treatment with NP4 but a poor ROS accumulation upon preincubation with NAC and subsequent treatment with NP4 (flow cytometry plots: Fig

Notably, three mutants showed more than a 50% increase in both glutathione parameters compared to the parental strain