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Fatty acid metabolites produced by gut microbiota, such as SCFAs, can cross the blood-brain barrier and influence the hypothalamic-pituitary-adrenal (HPA) axis, stimulating the secretion of gut hormones such as glucagon-like peptide-1 (GLP-1) and peptide tyrosine tyrosine (PYY), which in turn regulate lipid metabolism and inflammatory responses [192, 193]
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Its safe to inject Wegovy while its still cold, but some people find it more comfortable if the pen warms up to room temperature first
Dulaglutide is approved for T2DM management (Sanford, 2014), offering glycemic control and weight loss benefits comparable to liraglutide but with the added convenience of a weekly dosing regimen (Chang et al., 2020)
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