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Status of GLP-1RA drug in developing MASLD indication Generally, targeted drugs include single GLP-1R agonists and co-agonists, as well as combination formulations, innovative oral peptide preparations, and non-peptide small molecule agonists

Another study showed that in JHU-083-treated cancer cell allograft models, an increase in nutrient levels and oxygen and a decrease in the acidity of the TME resulted in T-cell-mediated tumor suppression 145 , whereas another study demonstrated the effects of JHU-083 on myeloid-derived suppressor cells (MDSCs) and TAMs 150