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Brnden, A., Knop, F

Oral semaglutide requires a higher dose than injectable medication since the bioavailability is lower

Because rodents lack the emetic reflex ( 28 ), pica behavior (i.e., ingestion of nonnutritive substances such as kaolin clay) is used in rats as a validated proxy for ongoing nausea/malaise ( 29 31 ) in response to treatments that induce nausea and vomiting in humans, including GLP-1 analogs