A New Obesity Definition Because BMI is such a flawed metric, the Lancet Commissionmade up of 58 experts from multiple medical specialties and countriesin 2025 recommended redefining overweight as preclinical obesity. 5 And earlier this year, the European Association for the Study of Obesity (EASO) released a new obesity definition that includes many people who previously would have been considered overweight
The significant weight loss to date will be due to the combination of Mounjaro and the formation of healthy lifestyle habits, such as eating the right foods, avoiding unhealthy foods, and exercising more regularly
However, tirzepatide appears to be a potential option in people with type 1 diabetes with problematic insulin resistance, but currently only on a case-by-case basis with careful counseling of risks, alongside usual insulin therapy. Berry and Iqbal said future studies should also examine whether benefits with tirzepatide are seen only in those with type 1 diabetes and obesity or among a broader group of adults with type 1 diabetes
Based on available clinical data, retatrutide produced significantly greater weight loss (-24.2% at 48 weeks) than semaglutide (-16.0% at 68 weeks) in their respective trials