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Primary adrenal insufficiency: managing mineralocorticoid replacement therapy
Reported Adverse Effects Reported adverse effects from online forums cited in a 2025 systematic review (PMC12313605) included: Anxiety and panic attacks Depression and anhedonia Insomnia Heart palpitations Fatigue and weakness Loss of appetite These anecdotal reports cannot be verified as directly caused by BPC-157 versus contamination, incorrect dosing, or concurrent conditions, but they raise concerns that the peptide might paradoxically worsen mental health in some individuals
First, the number of studies included for some outcomes, particularly renal outcomes, was relatively small, which may limit the generalizability of the findings
The two most significant incretin hormones are GLP-1 and glucose-dependent insulinotropic polypeptide (GIP)
