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Infectious agents also make toxins in the body, against which vitamin C provides an adequate defense

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Skin reactions or injection site effects may occur with B12 supplementation but are not caused by elevated serum levels

Over multiple cycles, this contributes to: Physical aggregation (clumping) of peptide molecules Potential denaturation of three-dimensional structure Gradual loss of biological activity in research assays The practical solution is simple: aliquot before freezing