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Research involving 75 women showed that sublingual Epithalon administration (0.5 mg/day for 20 days) significantly modulated expression of key circadian rhythm genes

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The use of claim 28 wherein the peptide Ac-Nle-cycVo(-Asp-His-D-Phe-Arg-Trp-Lys)- OH is employed for manufacture of a medicament for treatment by nasal administration and the PDE-5 inhibitor is employed for manufacture of a medicament for treatment by oral administration