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"Anything taken orally, only 20 to 40 per cent will get absorbed into the bloodstream as the rest gets destroyed in the stomach

If itching persists despite these measures, or if it significantly affects daily activities or sleep, patients should contact their healthcare team for further assessment

Nausea was often reported during dose escalation, with 1017% 6 of participants discontinuing treatment across dose cohorts due to GI symptoms

The cancers included in the study were gallbladder, colorectal, ovarian, endometrial, kidney, esophageal, liver, multiple myeloma, meningioma and pancreatic cancerswhich are all obesity-related cancers