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Upon ligand binding, GLP-1R activation enhances glucose-dependent insulin secretion, suppresses glucagon release, delays gastric emptying, and reduces appetite, collectively improving glycemic control and promoting clinically meaningful weight reduction [19]

Many patients notice the strongest appetite reduction around weeks 3 to 4 of each new dose level, which frequently coincides with the most noticeable weekly losses

The article also says the provider should review all medications, supplements and medical conditions first, and describes shared decision-making rather than automatic prescription as the appropriate route into treatment

Orthostatic hypotension in type 2 diabetes: Prevalence and risk factors