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GLP-1 RA treatment might be expected to improve HF outcome by augmenting glucose uptake by the myocardium, a potentially important mechanism in HF as fatty acid metabolism is down-regulated, and adenosine triphosphate synthesis is more dependent on glucose

There are two primary classes of GST prodrugs

Ensure adequate essential amino acids (lysine and methionine) for endogenous carnitine synthesis [1]

Science 314:130133 Held A, Adler M, Marques C et al (2023) iPSC motor neurons, but not other derived cell types, capture gene expression changes in postmortem sporadic ALS motor neurons