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This occurs as a result of a protein-enriched diet, and leads to detection of increased portal glucose and signaling to the hypothalamic nuclei, which regulate food intake (136)

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In multiple pathological settings, affected cells are not distributed randomly, but instead form contiguous zones of degeneration, synchronized tubular epithelial loss, aligned myofiber injury, or expanding fronts of tissue damage, patterns that are difficult to reconcile with strictly cell-autonomous execution