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Here we conducted five cohort studies to assess the effectiveness of tirzepatide and semaglutide in patients with elevated cardiovascular risk, including obesity and type 2 diabetes, enrolled in insurance programs in the USA between 2018 and 2025
doi: 10.1111/jdi.12488 45 NauckMAMeierJJ
Members at or near goal weight optimizing body composition Patients who tolerated standard GLP-1 dosing poorly but want the metabolic benefit Members layering the protocol into a coordinated primary care or mental health strategy Patients with significant weight to lose who would be better served by a standard GLP-1 protocol Personal or family history of medullary thyroid carcinoma or MEN 2 Pregnancy, breastfeeding, or planning pregnancy Expected Timeline What to Expect Microdosing is measured in composition, energy, and how you feel not weekly weigh-ins
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