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Previously, it was believed that metformin targets the liver and exerts its hypoglycemic effect through AMPK-dependent and non-AMPK-dependent pathways
If you need to continue increasing beyond 7.5 mg, maintain four-week intervals between increases (7.5 mg to 10 mg, then 10 mg to 12.5 mg, then 12.5 mg to 15 mg)
Do not repeat the protocol without reducing each dose by at least 40% and introducing 812 hour spacing
The key process entails CD-1 initiating autophagy in pancreatic -cells via the AMPK/mTOR/UNC-52-like kinase 1 (ULK1) pathway
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