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We hypothesised that the reported brainstem transcriptomic changes might reflect modulation of NTS Ppg neuron activity downstream of GIPR antagonism in the hypothalamus and therefore tested the effect of GIPR-antag on mice with ablated NTS Ppg neurons (Ppg NTS-Abl ) generated by bilateral stereotactic injection of AAV-DTA into the NTS of Ppg-Cre or control mice (Cre-negative mice receiving AAV-DTA into the NTS) (Fig

This quality makes it a stable gastric peptide that maintains its bioactivity whether administered orally or parenterally, allowing it to exert systemic effects

Its actions include suppressing glucagon secretion, delaying gastric emptying, increasing energy expenditure and promoting satiety