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Heat and light are the enemies of reconstituted peptides
As GPL-1RAs are priced higher than both SGLT-2is and DDP-4is, whether semaglutide represents a cost-effective treatment relative to comparator DDP-4i and SGLT-2is is of interest
however, concomitant metformin therapy was not associated with an increased risk of GI symptoms, or an increased likelihood of GLP-1 RA discontinuation, compared to those who were not taking metformin
For example, patients can be advised to report persistent upper abdominal pain, fever, or jaundice
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