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Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells

Abbreviations ADC: Antibodydrug conjugate ATRi: Ataxia telangiectasia and Rad3-related protein inhibitor ATMi: Ataxia telangiectasia mutated protein inhibitor BCRP: Breast cancer drug resistance protein BER: Base excision repair ceRNA: Competitive endogenous RNA CHK1/2: Checkpoint kinase 1/2 CSC: Cancer stem cell DAPT: N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester DDR: DNA damage repair DHMEQ: Dehydroxymethylepoxyquinomicin DNMTi: DNA methyltransferase inhibitor DOK2: Docking protein 2 DYNLL1: Dynein light chain 1 EAH2: Zeste homologue 2 EMT: Epithelial mesenchymal transformation ER: Endoplasmic Reticulum FANC: Fanconi anemia complementation group GST: Glutathione transferase HDACs: Histone deacetylase Hh: Hedgehog HRD: Homologous recombination deficiency HRR: Homologous recombination repair HGSOC: High-grade serous ovarian cancer HSP: Heat shock protein LGSC: Low grade serous carcinoma LRP: Lung drug resistance-related protein MMR: Mismatch repair MRP: Multidrug resistance-related protein NCCN: National Comprehensive Cancer Network ncRNA: Non-coding RNA NHEJ: Non-homologous end junction NER: Nucleotide excision repair OS: Overall survival PARPi: Poly ADP-ribose polymerase inhibitor PFS: Progression-free survival P-gp: P-glycoproteins SHLD: Shieldin TGF-: Transforming growth factor-beta TIL: Tumor-infiltrating lymphocytes TLS: Translesion DNA synthesis TEAD: TEA domain family UCA1: Urothelial carcinoma-associated 1 3-UTR: 3-Untranslated region XIAP: X-linked inhibitor of apoptosis YAP: Yes-associated protein References Cortez AJ, Tudrej P, Kujawa KA, Lisowska KM

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