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Association between plasma IL-6 response to acute stress and early-life adversity in healthy adults
P.Mohd-RedzwanS

it predates modern trial standards for the adult uses now marketed

Hence it stands to reason that there must be evidence of such stress pre-recruitment, or its confident expectation on the basis of numerous published reports - provided that ineligible patients are excluded and that patients do not change their lifestyles for the duration of a trial

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