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Key points Amyotrophic lateral sclerosis (ALS), with a lifetime risk of ~1/350, represents an area of huge unmet need and is a useful model of neurodegeneration, with measurable changes in motor function over a relatively short time frame
The common technique mistakes Most problems trace back to a handful of errors: using the wrong needle length so the dose lands in fat rather than muscle, not cleaning the skin, injecting too fast, injecting at the wrong angle, or reusing a needle
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