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For many patients, the clinical benefits of GLP-1sparticularly sustained weight loss and metabolic improvementsare closely tied to continued use.[166] Once treatment is discontinued, individuals often experience weight regain and the return of obesity-related health conditions, underscoring the need to view obesity as a chronic condition that may require long-term treatment.[167] Adherence is also influenced by treatment tolerability.[168] While GLP-1s are generally well tolerated, side effects such as gastrointestinal symptoms and the inconvenience of regular self-injections may deter adherence for certain patients.[169] Recognizing the challenges associated with long-term adherence, pharmaceutical companies are innovating through the development of more-convenient delivery methods
Clinical observations indicate that patients often achieve over 15% body weight loss, leading to improved metabolic health and enhanced reproductive function
Please note that results vary
Pulikkottil completed a demanding three-year Fellowship in Plastic and Reconstructive Surgery at the prestigious University of Texas at Southwestern, as well as an elite Microsurgery Fellowship at the University of Pittsburgh Medical Center.
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