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demonstrated that the GLP-1 analogue lixisenatide decreases atherosclerosis in insulin-resistant Apoe/Irs2+/ mice by promoting macrophage polarization towards an anti-inflammatory M2 phenotype, which was associated with enhanced plaque stability (i.e., thicker fibrous caps, fewer necrotic cores, and decreased inflammatory infiltrates)
Gastroenterology 162 , 11971209.e13 (2022)
53 Future Directions and Unanswered Questions Despite recent evidence from clinical trials, key questions remain about the optimal use of GLP-1RAs for HF
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