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As the only enzyme of the cycle located on the outer surface of plasma membrane, gammaglutamyl transpeptidase (GGT) plays key roles in GSH homeostasis by breaking down extracellular GSH and providing cysteine, the ratelimiting substrate, for intracellular de novo synthesis of GSH

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Study selection Firstly, studies were assessed by title verification between databases (duplicates were removed)

Further Reading: The Different Types of Protein Calcium AKG Pros: Used in Glutathione Production: Calcium AKG is one of the precursors to glutathione