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In two head-to-head comparisons, a small, transient mean increase in HR from baseline was observed with lixisenatide

Genetics, metabolism, and underlying health conditions all affect how someone responds to weight loss medication

ENDO 2025 data (Castaneda) found menopausal women on tirzepatide + MHT lost 18.7% body weight versus 13.7% in non-MHT users by month 15

Given that several further dual agonists are coming closer to becoming licenced, such as mazdutide and survodutide, with many more in development [15], combining licenced dual agonists with developing mono-agonists may be a faster way to develop effective treatments achieving triple agonism