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The magnitude of between-group differences corresponded to large effect sizes at both 3 and 6 months (d = 1.08 and d = 1.31, respectively), indicating a clinically meaningful advantage for semaglutide

The exceptional in vitro potency is attributed to its mechanism of acting as an allosteric potentiator of HGF binding to c-Met (amplifying an endogenous signal), which produces non-linear dose-response curves

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