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doi: 10.2337/db14-1577 44 ChoiEYangJJiGEParkMSSeongYOhSWet al

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Appetite suppression from the GLP-1 and GIP components appears well-maintained with microdosing, particularly at twice-weekly frequency

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This pathway not only suppresses CD8T cell infiltration but also downregulates major histocompatibility complex class I (MHC I) expression and inhibits interferon-gamma (IFN-) signaling, thereby undermining antitumor immune responses at multiple levels [85]

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