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PMID: 29224938

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13 NONCLINICAL TOXICOLOGY NONCLINICAL TOXICOLOGY SECTION 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility CARCINOGENESIS & MUTAGENESIS & IMPAIRMENT OF FERTILITY SECTION A 2-year carcinogenicity study was conducted with tirzepatide in male and female rats at doses of 0.15, 0.50, and 1.5 mg/kg (0.1-, 0.4-, and 1-fold the MRHD of 15 mg once weekly based on AUC) administered by subcutaneous injection twice weekly