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Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation

Criteria for inclusion and exclusion This study incorporated only those investigations that fulfilled specific inclusion criteria: publications in the English language, studies involving subjects diagnosed with type 2 diabetes mellitus (T2D), randomized controlled trials (RCTs), interventions that compared the efficacy of SGLT-2 inhibitors or GLP-1 receptor agonists against placebo, and reports on major adverse cardiovascular events (MACE) or hospitalization for heart failure (HHF), as well as cardiovascular outcomes irrespective of baseline metformin usage

People with higher incomes or generous private insurance plans will continue treatment

Acknowledgements We thank M