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Absolutley and it fact it is recommended
Clinical Significance Methotrexate remains one of the most important drugs in oncology and rheumatology due to its efficacy and cost-effectiveness
As many treatments for neurological conditions have been hampered by limited permeability of the BBB, significant emphasis has been placed on research directed towards advanced drug delivery methods (Liu et al., 2025)
Switch to a non-oral contraceptive method or use an additional barrier method (e.g., condoms) for 4 weeks after starting this medicine and for 4 weeks after each dose escalation
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