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This knowledge now opens novel ways to improve interventions that could combat age-related muscle atrophy and impaired regeneration with fibrosis and fat infiltration (including sarcopenia and frailty)

Physiologically, Fe + -bound transferrin (TF) is internalized via transferrin receptor 1 (TFR1), reduced to Fe + and transported by divalent metal transporter 1 (DMT1) into the labile iron pool (LIP) or ferritin ( + to trigger Fenton reaction, ROS production, LPO and ferroptosis

Immature cataracts are determined as those occurring in lenses with significant areas of translucency

The glutathione redox ratio (GSH: GSSG) is an indicator of overall glutathione status and intracellular reducing environment