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In Alzheimer's disease, diminished tau lactylation suppresses ferritinophagy, resulting in iron accumulation and altered susceptibility to ferroptosis, highlighting the complex interplay among lactate metabolism, autophagy and iron homeostasis (119)
10.1152/ajprenal.00574.2014 32 HuJ
Detoxification Support Glutathione is widely known for supporting the bodys natural detoxification process
sgRNA constructs and gene expressing codon optimized (OPT) plasmid constructs sgRNA control and constructs against CBS and L2HGDH were designed targeting GTATTACTGATATTGGTGGG (sgControl) (#230080, Addgene), GGAGCAGACAACCTACGAGG (sg CBS -1) (#230081, Addgene), TGGCAGTGCTGGCAGCACGG (sg CBS -2) (#230082, Addgene), GATATAGTCATCGTTGGTGG (sg L2HGDH -1) (#230083, Addgene), and CACCAGACTGGACATAACAG (sg L2HGDH -2) (#230084, Addgene) and constructed in lentiCRISPR v2-Blast (#83480, Addgene) for Blasticidin selection at a final concentration of 5 g/ml
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