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The LEADER trial (liraglutide) and SUSTAIN-6 trial (semaglutide) demonstrated cardiovascular risk reduction over multi-year follow-up periods (approximately 3.8 years and 2.1 years, respectively)

Should You Consider a B12 Shot

Figure 3 3.3.2 Efficacy of GLP-1 RAs on liver enzymes in MASLD Twenty reviews of the 24 meta-analyses examined the efficacy of GLP-1 RAs on liver enzymes, including ALT, AST, GGT, and ALP (Supplementary Table S6)

The 6-month wait is outdated and harmful : Current guidelines requiring 6 months of behavioral therapy before medication lead to high dropout rates (53-70% of early non-responders fail to achieve 5% weight loss) and treatment abandonment